Recurrence of an allergic inflammation of air-pouch type in rats and possible participation of prostaglandin E2.

Abstract	The recurrence of allergic inflammation, as examined by exudate accumulation, infiltration of polymorphonuclear leukocytes into the exudate, edema formation, vascular permeability and prostaglandin E2 levels in the exudate, was induced by injecting the antigen, azobenzene arsonate-conjugated acetyl bovine serum albumin, into the capsule of the proliferative granulation tissue which had been formed by the first-time antigenic challenge injection into an air pouch in the dorsum of the sensitized rat. The recurrence of the allergic inflammation 4 and 24 h after the antigenic challenge was inhibited dose-dependently by treatment with cyclooxygenase inhibitors, suggesting the possible participation of cyclooxygenase products, especially prostaglandin E2. The difference in the allergic inflammatory responses induced by the first-time antigenic challenge and the second-time antigenic challenge was discussed from the viewpoint of chemical mediators.
Authors	M Watanabe, K Ohuchi, S Tsurufuji
Journal	International archives of allergy and applied immunology (Int Arch Allergy Appl Immunol) Vol. 83 Issue 4 Pg. 390-7 ( 1987) ISSN: 0020-5915 [Print] Switzerland
PMID	3112027 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Arsenicals Azo Compounds Cyclooxygenase Inhibitors Prostaglandins E Serum Albumin, Bovine azobenzene Dinoprostone
Topics	Animals Arsenicals (adverse effects, immunology) Azo Compounds (adverse effects, immunology) Capillary Permeability (drug effects) Cell Movement Cyclooxygenase Inhibitors Dinoprostone Disease Models, Animal Dose-Response Relationship, Drug Exudates and Transudates (cytology) Hypersensitivity, Immediate (chemically induced, immunology, physiopathology) Immunization Inflammation (immunology) Leukocytes (cytology, drug effects, immunology) Male Neutrophils (drug effects, physiology) Prostaglandins E (analysis, immunology) Rats Rats, Inbred Strains Serum Albumin, Bovine (adverse effects, immunology) Time Factors

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