Abstract | OBJECTIVE: DESIGN AND PATIENTS: This retrospective propensity score-matched cohort study included 720 PTC patients who received RAIT for <90 or 90-180 days (early and delayed groups, n = 360 each) after thyroidectomy. Responses to therapy, disease-free survival (DFS) and overall survival (OS) were compared between the two groups. RESULTS: After matching, the baseline characteristics of the 360 patients in each group were similarly adjusted. Within the first 2 years after initial therapy, the number of patients classified into excellent, indeterminate, biochemical incomplete and structural incomplete response categories were 221 (61%), 74 (21%), 39 (11%) and 26 (7%) in the early group, and 204 (57%), 73 (20%), 59 (16%) and 24 (7%) in the delayed group, respectively. There was no significant difference in response to therapy between the two groups (P = 0.183). During the median follow-up of 8.6 years, there was no significant difference in DFS (P = 0.060) and OS (P = 0.400) curves between the two groups. Delayed RAIT was not significantly associated with worse DFS (HR = 1.3, 95% CI 0.9-1.8, P = 0.061) or OS (HR = 1.5, 95% CI 0.6-3.4, P = 0.388). CONCLUSIONS: Delaying the first RAIT until 180 days after total thyroidectomy had no impact on restaging, recurrence and mortality in intermediate-to-high-risk PTC.
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Authors | Mijin Kim, Minkyu Han, Min Ji Jeon, Won Gu Kim, In Joo Kim, Jin-Sook Ryu, Won Bae Kim, Young Kee Shong, Tae Yong Kim, Bo Hyun Kim |
Journal | Clinical endocrinology
(Clin Endocrinol (Oxf))
Vol. 91
Issue 3
Pg. 449-455
(09 2019)
ISSN: 1365-2265 [Electronic] England |
PMID | 31102417
(Publication Type: Journal Article)
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Copyright | © 2019 John Wiley & Sons Ltd. |
Chemical References |
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Topics |
- Adult
- Cohort Studies
- Female
- Humans
- Iodine Radioisotopes
(therapeutic use)
- Male
- Middle Aged
- Retrospective Studies
- Survival Analysis
- Thyroid Cancer, Papillary
(mortality, radiotherapy, surgery)
- Thyroidectomy
- Time-to-Treatment
- Treatment Outcome
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