Abstract |
SK&F 86002 [6-(4-fluorophenyl)2,3-dihydro-5-(4-pyridinyl)imidazo (2,1-b) thiazole], a dual inhibitor of arachidonic acid metabolism, administered orally to rats prevented the development of carrageenan-induced edema, immune- and nonimmune-mediated inflammation of adjuvant-induced arthritis (AA) and reduced established inflammation in AA and collagen type II-induced arthritis. A similar profile of activity was observed following treatment with the cyclooxygenase inhibitor, indomethacin. However, unlike other nonsteroidal antiinflammatory drugs, SK&F 86002 exhibited antiinflammatory activity in inflammation models that are insensitive to cyclooxygenase inhibitors such as the established inflammation in carrageenan-induced edema and the edema induced by arachidonic acid and platelet activating factor. Moreover, SK&F 86002, but not indomethacin, inhibited the immune-mediated inflammatory responses evoked in sensitized animals by challenge with purified protein derivative. In addition, SK&F 86002 produced dose-related analgesia in mice, which was not reversed by the narcotic antagonist, naltexone. SK&F 86002 thus represents an orally active antiarthritic and analgesic compound with novel antiinflammatory properties.
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Authors | M J DiMartino, D E Griswold, B A Berkowitz, G Poste, N Hanna |
Journal | Agents and actions
(Agents Actions)
Vol. 20
Issue 1-2
Pg. 113-23
(Feb 1987)
ISSN: 0065-4299 [Print] Switzerland |
PMID | 3107354
(Publication Type: Journal Article)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Cyclooxygenase Inhibitors
- Imidazoles
- Lipoxygenase Inhibitors
- Thiazoles
- 6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole
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Topics |
- Administration, Oral
- Analgesia
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(therapeutic use)
- Arthritis, Experimental
(drug therapy)
- Cyclooxygenase Inhibitors
- Edema
(drug therapy)
- Imidazoles
(therapeutic use)
- Lipoxygenase Inhibitors
- Male
- Rats
- Rats, Inbred Lew
- Thiazoles
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