A natural cordycepin/chitosan complex hydrogel with outstanding self-healable and wound healing properties.
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| Abstract |
The chitosan-based hydrogel dressings have been intensively engaged in wound healing. In respect to the relatively unsatisfied anti-bacterial performance of chitosan, we developed a self-healable cordycepin (abbreviated to CY)/chitosan (abbreviated to CS) hydrogel dressing cross linking by non-covalent bonds (hydrogen bond and electrostatic interaction) for wound healing through one-step 'freeze-thaw' method without adding any cross-linking agent. The as-prepared hybrid hydrogel exhibited excellent biocompatibility, suitable swelling ratio and desired mechanical strength, providing remarkable antimicrobial effect with no side effects in vitro. The self-healable property enables this hydrogel to adapt irregularly shaped wound defects without premolding. Moreover, our in vivo experiments confirmed that CY/CS hydrogel served as a quicker re-epithelization of skin wounds and an apparent increasing collagen deposition compared with chitosan hydrogels. Additionally, the CY/CS hydrogel significantly increased the expressions of epithelial regeneration markers including laminin and involucrin. The present study highlights a facile hydrogel strategy to balance and optimize the biocompatibility, swelling ratio and self-adapting ability for treating wound healing.
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| Authors | Ruru Song, Jun Zheng, Yilin Liu, Yun Tan, Zhaoyu Yang, Xianwen Song, Songqin Yang, Rong Fan, Yi Zhang, Yang Wang |
| Journal | International journal of biological macromolecules (Int J Biol Macromol) Vol. 134 Pg. 91-99 (Aug 01 2019) ISSN: 1879-0003 [Electronic] Netherlands |
| PMID | 31067486 (Publication Type: Journal Article) |
| Copyright | Copyright © 2019 Elsevier B.V. All rights reserved. |
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