Vitamin D Supplementation in France in patients with or at risk for osteoporosis: Recent data and new practices.

Abstract

With intermittent vitamin D supplementation, serum 25-hydroxyvitamin D (25OHD) levels may remain stable only if the dosing interval is shorter than 3 months, the ideal perhaps being about 1 month. Recent data support moderate daily vitamin D doses instead of high intermittent doses, notably in elderly patients prone to falls. The level of evidence is low, however, with no head-to-head comparisons of clinical outcomes such as fractures and falls in groups given identical dosages daily versus intermittently. A challenge to daily vitamin D supplementation in France is the absence of a suitable pharmaceutical formulation. In addition, daily dosing carries a high risk of poor adherence. Until suitable vitamin D3 formulations such as tablets or soft capsules each containing 1000 or 1500 IU become available, we suggest intermittent supplementation according to 2011 GRIO guidelines. Among the available dosages, the lowest should be preferred, with the shortest possible interval, e.g., 50,000 IU monthly rather than 100,000 every two months.

• Authors: Jean-Claude Souberbielle, Catherine Cormier, Etienne Cavalier, Véronique Breuil, Françoise Debiais, Patrice Fardellone, Pascal Guggenbuhl, Rose-Marie Javier, Erick Legrand, Eric Lespessailles, Julien Paccou, Thierry Thomas, Bernard Cortet, au nom du Groupe de recherche et d’information sur les ostéoporoses, (GRIO)
• Journal: Joint bone spine (Joint Bone Spine) Vol. 87 Issue 1 Pg. 25-29 (Jan 2020) ISSN: 1778-7254 [Electronic] France
• PMID: 31051244 (Publication Type: Journal Article)
• Copyright: Copyright © 2019 Société française de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.

Chemical References

• Vitamin D
• Cholecalciferol

Topics

• Aged
• Cholecalciferol
• Dietary Supplements
• France (epidemiology)
• Humans
• Osteoporosis (drug therapy, epidemiology, prevention & control)
• Vitamin D
• Vitamin D Deficiency