A Catalase-Like Metal-Organic Framework Nanohybrid for O2 -Evolving Synergistic Chemoradiotherapy.

Abstract

Tumor hypoxia, the "Achilles' heel" of current cancer therapies, is indispensable to drug resistance and poor therapeutic outcomes especially for radiotherapy. Here we propose an in situ catalytic oxygenation strategy in tumor using porphyrinic metal-organic framework (MOF)-gold nanoparticles (AuNPs) nanohybrid as a therapeutic platform to achieve O2 -evolving chemoradiotherapy. The AuNPs decorated on the surface of MOF effectively stabilize the nanocomposite and serve as radiosensitizers, whereas the MOF scaffold acts as a container to encapsulate chemotherapeutic drug doxorubicin. In vitro and in vivo studies verify that the catalase-like nanohybrid significantly enhances the radiotherapy effect, alleviating tumor hypoxia and achieving synergistic anticancer efficacy. This hybrid nanomaterial remarkably suppresses the tumor growth with minimized systemic toxicity, opening new horizons for the next generation of theranostic nanomedicines.

• Authors: Zhimei He, Xiaolin Huang, Chen Wang, Xiangli Li, Yijing Liu, Zijian Zhou, Sheng Wang, Fuwu Zhang, Zhantong Wang, Orit Jacobson, Jun-Jie Zhu, Guocan Yu, Yunlu Dai, Xiaoyuan Chen
• Journal: Angewandte Chemie (International ed. in English) (Angew Chem Int Ed Engl) Vol. 58 Issue 26 Pg. 8752-8756 (06 24 2019) ISSN: 1521-3773 [Electronic] Germany
• PMID: 31046176 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Metal-Organic Frameworks
• Catalase

Topics

• Catalase (chemistry)
• Chemoradiotherapy (methods)
• Humans
• Metal-Organic Frameworks (chemistry)