Abstract |
Prevention and treatment of malaria are endangered by the appearance of chemoresistance against the common anti-malarial drugs by Plasmodium falciparum. Today, only a quinoline derivative, mefloquine, is a safe and effective agent against P. falciparum. An in vitro antiplasmodial activity having been found for the quassinoid glaucarubinone we tested its in vivo therapeutic action on mice infected with a P. berghei strain. At low doses, glaucarubinone retarded mortality by exerting a partial, temporary, inhibition of parasitaemia; its toxicity, however, precludes, further applications at the present time.
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Authors | L Monjour, F Rouquier, C Alfred, J Polonsky |
Journal | Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie
(C R Acad Sci III)
Vol. 304
Issue 6
Pg. 129-32
( 1987)
ISSN: 0764-4469 [Print] France |
Vernacular Title | Essais de traitement du paludisme murin expérimental par un quassinoïde, la glaucarubinone. |
PMID | 3103880
(Publication Type: Comparative Study, English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Phenanthrenes
- glaucarubinone
- Glaucarubin
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Topics |
- Administration, Oral
- Animals
- Drug Evaluation, Preclinical
- Female
- Glaucarubin
(administration & dosage, analogs & derivatives, therapeutic use, toxicity)
- Injections, Intraperitoneal
- Malaria
(drug therapy)
- Mice
- Phenanthrenes
(therapeutic use)
- Plasmodium berghei
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