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[Therapeutic trials of experimental murine malaria with the quassinoid, glaucarubinone].

Abstract
Prevention and treatment of malaria are endangered by the appearance of chemoresistance against the common anti-malarial drugs by Plasmodium falciparum. Today, only a quinoline derivative, mefloquine, is a safe and effective agent against P. falciparum. An in vitro antiplasmodial activity having been found for the quassinoid glaucarubinone we tested its in vivo therapeutic action on mice infected with a P. berghei strain. At low doses, glaucarubinone retarded mortality by exerting a partial, temporary, inhibition of parasitaemia; its toxicity, however, precludes, further applications at the present time.
AuthorsL Monjour, F Rouquier, C Alfred, J Polonsky
JournalComptes rendus de l'Academie des sciences. Serie III, Sciences de la vie (C R Acad Sci III) Vol. 304 Issue 6 Pg. 129-32 ( 1987) ISSN: 0764-4469 [Print] France
Vernacular TitleEssais de traitement du paludisme murin expérimental par un quassinoïde, la glaucarubinone.
PMID3103880 (Publication Type: Comparative Study, English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Phenanthrenes
  • glaucarubinone
  • Glaucarubin
Topics
  • Administration, Oral
  • Animals
  • Drug Evaluation, Preclinical
  • Female
  • Glaucarubin (administration & dosage, analogs & derivatives, therapeutic use, toxicity)
  • Injections, Intraperitoneal
  • Malaria (drug therapy)
  • Mice
  • Phenanthrenes (therapeutic use)
  • Plasmodium berghei

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