Lymhocyte stimulatory effect of an ether-extracted preparation of Brucella abortus.

Abstract	The effect of a Brucella abortus preparation (Bru Pel) on the T- and B-lymphocyte populations is described. Bru Pel treatment of tumor-bearing mice resulted in a slight reduction in tumor size, marked splenomegaly, and statistically significant reductions in the percentages of splenic T and B lymphocytes relative to untreated tumor controls. Bru Pel was also found to cause increases in the incorporation of 3H-thymidine of phytohemagglutinin-sensitive splenic T lymphocytes and lipopolysaccharide-sensitive splenic B lymphocytes over 3H-thymidine-incorporated values for untreated tumor controls.
Authors	W A Stylos, M A Chirigos, C R Lengel
Journal	Cancer treatment reports (Cancer Treat Rep) Vol. 62 Issue 11 Pg. 1949-54 (Nov 1978) ISSN: 0361-5960 [Print] United States
PMID	310345 (Publication Type: Comparative Study, Journal Article)
Chemical References	Brucella Vaccine Carmustine
Topics	Animals B-Lymphocytes (pathology) Brucella Vaccine (pharmacology) Carmustine (pharmacology) Lung Neoplasms (immunology, pathology, therapy) Lymphocyte Activation Lymphocytes (immunology) Male Mice Mice, Inbred Strains Neoplasms, Experimental (therapy) Spleen (immunology, pathology) T-Lymphocytes (pathology)

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