Antitumor activity of protein-bound polysaccharide from Cordyceps ophioglossoides in mice.

Abstract

The effects of protein-bound polysaccharide (SN-C) extracted from Cordyceps ophioglossoides on the growth of transplanted allogeneic and syngeneic murine tumors were studied. SN-C given by intraperitoneal administration suppressed the growth of sarcoma-180 transplanted subcutaneously in mice. Intraperitoneal administration of SN-C also caused a significant prolongation of the life span of ICR mice inoculated intraperitoneally with Ehrlich carcinoma, and C3H/He mice inoculated intraperitoneally with a syngeneic tumor (X-5563). SN-C showed a significant cytocidal effect on cultured tumor cells. SN-C did not affect delayed-type hypersensitivity (DTH) in normal mice, but restored the depressed capacity to raise DTH in tumor-bearing mice. These results suggested that SN-C may exert both direct and host-mediated antitumor effects.

• Authors: T Ohmori, K Tamura, S Tsuru, K Nomoto
• Journal: Japanese journal of cancer research : Gann (Jpn J Cancer Res) Vol. 77 Issue 12 Pg. 1256-63 (Dec 1986) ISSN: 0910-5050 [Print] Japan
• PMID: 3102430 (Publication Type: Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• Proteoglycans
• protein-bound SN-C polysaccharide

Topics

• Animals
• Antibiotics, Antineoplastic (isolation & purification, pharmacology)
• Carcinoma, Ehrlich Tumor (drug therapy)
• Female
• Hypersensitivity, Delayed
• Hypocreales (chemistry)
• Mice
• Mice, Inbred C3H
• Mice, Inbred ICR
• Neoplasms, Experimental (drug therapy, immunology)
• Proteoglycans (isolation & purification, pharmacology)
• Sarcoma 180 (drug therapy)