Action of a prostaglandin synthetase inhibitor on IUD associated uterine bleeding.

Abstract

The Authors treated twenty-eight women using IUD, who suffered from increased menstrual blood loss and pelvic pain, with a prostaglandin synthetase inhibitor, Suprofen, in an attempt to reduce their symptomatology, in a double blind crossover study. The drug produced an important reduction of the menstrual blood loss and pains. These observations suggest that prostaglandins are involved in the etiology of excessive menstrual blood loss and pains, and that prostaglandin inhibitors may be useful for reducing these symptoms.

• Authors: A Di Lieto, D Catalano, L Miranda, A Paladini
• Journal: Clinical and experimental obstetrics & gynecology (Clin Exp Obstet Gynecol) Vol. 14 Issue 1 Pg. 41-4 ( 1987) ISSN: 0390-6663 [Print] Singapore
• PMID: 3102127 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Cyclooxygenase Inhibitors
• Phenylpropionates
• Suprofen

Topics

• Clinical Trials as Topic
• Cyclooxygenase Inhibitors
• Double-Blind Method
• Female
• Humans
• Intrauterine Devices (adverse effects)
• Menorrhagia (drug therapy)
• Phenylpropionates (therapeutic use)
• Suprofen (therapeutic use)