Abstract |
A new drug, gestrinone, was subjected to the first double blind, randomised placebo controlled trial of any treatment of endometriosis. The disease deteriorated in eight (47%) of the 17 patients prescribed placebo (95% confidence limits 23% and 71%) compared with none of the 18 patients prescribed gestrinone (p = 0.002). There was a difference in elimination of the endometriosis in the gestrinone group compared with placebo but this was not statistically significant (p = 0.057). There was a significant difference in improvement of the disease in the gestrinone group compared with placebo (p = 0.004), confirming that gestrinone is an effective treatment of endometriosis. Endometriosis deteriorates in at least 23% of patients; as it is impossible to predict in whom this will happen, treatment appears to be warranted in all cases.
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Authors | E J Thomas, I D Cooke |
Journal | British medical journal (Clinical research ed.)
(Br Med J (Clin Res Ed))
Vol. 294
Issue 6567
Pg. 272-4
(Jan 31 1987)
ISSN: 0267-0623 [Print] England |
PMID | 3101839
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Norpregnatrienes
- Gestrinone
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Topics |
- Adult
- Clinical Trials as Topic
- Double-Blind Method
- Endometriosis
(drug therapy)
- Female
- Gestrinone
(therapeutic use)
- Humans
- Norpregnatrienes
(therapeutic use)
- Random Allocation
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