Abstract | OBJECTIVES: METHODS: Our study was a parallel-group, double-blind, randomized trial involving 71 patients with recalcitrant elbow tendinopathy who received two sessions of ultrasound-guided tenotomy with either PRP or lidocaine in a tertiary public hospital. The primary end point was the percentage of patients with an improvement exceeding 25% reduction in disability (Spanish version of the Disabilities of the Arm, Shoulder and Hand questionnaires-DASH-E) at 6 and 12 months; the secondary outcome was the percentage of patients exceeding 25% reduction in pain (VAS-P). RESULTS: There was no evidence of significant differences in the proportion of patients who experienced clinically relevant improvements. After 6 months, 18 patients (78.59%) in the lidocaine group and 19 patients (73.08%) in the PRP group showed improved function above 25% (unadjusted odds ratio, 0.90; 95% confidence interval [CI], 0.90 (0.17 to 4.60)); 21 patients (72.21%) in the lidocaine group versus 22 patients (84.62%) in the PRP group achieved more than 25% pain reduction (unadjusted odds ratio, 0.48; 95% CI, 0.10 to 2.37). After 12 months, 17 patients (70.83%) in the lidocaine group versus 19 patients (76%) in the PRP group had improved function (unadjusted odds ratio, 0.71; 95% CI, 0.13 to 3.84), and 19 patients (76%) in the lidocaine group versus 20 patients (90.91%) in the PRP group had improved pain above 25% (unadjusted odds ratio, 0.35; 95% CI, 0.06 to 2.51). Hypercholesterolemia and baseline vascularization influenced outcomes. There were no differences between groups in the adjusted odds ratios. CONCLUSION: PRP results in similar improvements to those obtained with lidocaine. Selecting patients according to their pretreatment status can improve treatment efficacy. TRIAL REGISTRATION: NCT01945528 , EudraCT 2013-000478-32. Registered 18 August 2013, enrolment of the first participant 10 March 2014.
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Authors | Jose Ignacio Martin, Leire Atilano, Josu Merino, Igor Gonzalez, Gotzon Iglesias, Luis Areizaga, Paola Bully, Gonzalo Grandes, Isabel Andia |
Journal | Journal of orthopaedic surgery and research
(J Orthop Surg Res)
Vol. 14
Issue 1
Pg. 109
(Apr 23 2019)
ISSN: 1749-799X [Electronic] England |
PMID | 31014382
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anesthetics, Local
- Lidocaine
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Topics |
- Adult
- Anesthetics, Local
(administration & dosage)
- Double-Blind Method
- Female
- Humans
- Lidocaine
(administration & dosage)
- Male
- Middle Aged
- Platelet-Rich Plasma
- Tennis Elbow
(diagnostic imaging, drug therapy, surgery)
- Tenotomy
(methods)
- Ultrasonography, Interventional
(methods)
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