Abstract |
The generation of immune cells from human pluripotent stem cells (embryonic stem cells and induced pluripotent stem cells) has been of keen interest to regenerative medicine. Pluripotent stem cell-derived immune cells such as natural killer cells, macrophages, and lymphoid cells, especially T cells, can be used in immune cell therapy to treat incurable cancers. Moreover, since the advent of chimeric antigen receptor (CAR) technology, the success of CAR-T cells in the clinic has galvanized new efforts to harness the power of CAR technology to generate CAR-engineered immune cells from pluripotent stem cells. This review provides a summary of pluripotent stem cell-derived immune cells and CAR technology, together with perspectives on combining pluripotent stem-cell derived immune cells and CAR engineering to pave a new way for developing next generation immune cell therapy.
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Authors | Jung Min Lee |
Journal | International journal of molecular sciences
(Int J Mol Sci)
Vol. 20
Issue 8
(Apr 12 2019)
ISSN: 1422-0067 [Electronic] Switzerland |
PMID | 31013813
(Publication Type: Journal Article, Review)
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Chemical References |
- Receptors, Antigen, T-Cell
- Receptors, Chimeric Antigen
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Topics |
- Animals
- Cell Differentiation
(immunology)
- Humans
- Immunotherapy
- Killer Cells, Natural
(immunology, metabolism)
- Pluripotent Stem Cells
(cytology, metabolism)
- Receptors, Antigen, T-Cell
(genetics, metabolism)
- Receptors, Chimeric Antigen
(genetics, metabolism)
- Stem Cell Transplantation
- Stem Cells
(cytology, metabolism)
- T-Lymphocytes
(immunology, metabolism)
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