Women with
endometrial cancer (EC) frequently receive adjuvant
paclitaxel and
carboplatin (PC)
chemotherapy. There is no standard first line
chemotherapy at disease recurrence. Data extrapolated from
ovarian cancer has suggested that patients with recurrent EC may benefit from further
platinum-based
chemotherapy. We performed a retrospective analysis of patients who were retreated with PC
chemotherapy for recurrent EC at Memorial Sloan Kettering
Cancer Center between January 2000 and December 2014. The median progression free survival (PFS) and overall survival (OS) were estimated using the Kaplan Meier method. Twenty patients were included in the analysis. Patients were re-treated with PC a median of 25 (8-79) months from their original PC. There were no complete responses, 10 (50%) patients had partial response (PR), 3 (15%) had stable disease, 2 (10%) had progression at best response and 5 (20%) were not evaluable by RECIST. A median of 6 cycles of PC were administered (2-9). Four patients (20%) transitioned to
paclitaxel only due to
carboplatin allergy. At the data cut off, one patient continued PC, and another was off
therapy with PR. The remainder (N = 18, 90%) received a median of 2.5 (1-6) further lines of treatments. Median PFS and OS from re-treatment were 10 and 27 months respectively. Median OS from original diagnosis was 74 months. In this small retrospective study, selected patients with recurrent EC who are >6 months from completion of PC derive benefit from
retreatment with PC with a response rate of 50%.