In Vitro Anticancer Properties of Copper Metallodendrimers.

Abstract

Newly synthesized carbosilane copper dendrimers (CCD) with chloride and nitrate surface groups seem to be good candidates to be used as gene and drug carriers in anti-cancer therapy, due to their properties such as size and surface charge. Copper attached to the nanoparticles is an important element of many biological processes and recently their anti-cancer properties have been widely examined. Zeta size and potential, transmission electron microscopy (TEM), circular dichroism (CD), analysis of haemolytic activity, and fluorescence anisotropy techniques were used to characterize copper dendrimers. Additionally, their cytotoxic properties toward normal (PBMC) and cancer (1301; HL-60) cells were examined. All tested dendrimers were more cytotoxic against cancer cells in comparison with normal cells.

• Authors: Marcin Hołota, Jakub Magiera, Sylwia Michlewska, Małgorzata Kubczak, Natalia Sanz Del Olmo, Sandra García-Gallego, Paula Ortega, F Javier de la Mata, Maksim Ionov, Maria Bryszewska
• Journal: Biomolecules (Biomolecules) Vol. 9 Issue 4 (04 18 2019) ISSN: 2218-273X [Electronic] Switzerland
• PMID: 31003561 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Dendrimers
• Copper

Topics

• Antineoplastic Agents (chemistry, pharmacology, toxicity)
• Cell Line, Tumor
• Cells, Cultured
• Copper (chemistry)
• Dendrimers (chemistry, pharmacology, toxicity)
• Hemolysis
• Humans
• Monocytes (drug effects)