In vitro activity of SCH-34343, a new penam, and other antimicrobial agents against clinical isolates from cancer patients.

Abstract

The in vitro activity of SCH-34343, a new penam antibiotic, was tested against gram-positive and gram-negative isolates from cancer patients, and compared to that of 7 other antimicrobial agents. SCH-34343 was extremely active against the Enterobacteriaceae with MIC90 ranging from 0.39 to 6.25 micrograms/ml for Citrobacter spp., Enterobacter spp., Escherichia coli, Klebsiella spp., Proteus spp. and Serratia marcescens. It was less active against Acinetobacter spp. (MIC90 6.25-12.5 micrograms/ml) and had poor activity against Pseudomonas aeruginosa. Among gram-positive isolates group A and G beta-hemolytic Streptococci were extremely susceptible to SCH-34343 (MIC90 0.025-0.05 micrograms/ml). Good activity against methicillin-susceptible coagulase-positive and coagulase-negative Staphylococci and Listeria monocytogenes, and moderate activity against Enterococci was also seen.

• Authors: K V Rolston, M E Alvarez, J F Hoy, H C Alderman, D H Ho, G P Bodey
• Journal: Chemotherapy (Chemotherapy) Vol. 32 Issue 6 Pg. 506-14 ( 1986) ISSN: 0009-3157 [Print] Switzerland
• PMID: 3100147 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Lactams
• Sch 34343

Topics

• Anti-Bacterial Agents (pharmacology)
• Enterobacteriaceae (drug effects)
• Gram-Negative Bacteria (drug effects, isolation & purification)
• Gram-Positive Bacteria (drug effects, isolation & purification)
• Humans
• Lactams
• Listeria monocytogenes (drug effects)
• Microbial Sensitivity Tests
• Neoplasms (microbiology)
• Staphylococcus (drug effects)
• Streptococcus (drug effects)