Neurofibromatosis in a man with a ring 22: in situ hybridization studies.

Abstract

In situ hybridization with a c-sis probe was performed on peripheral lymphocytes of a man with neurofibromatosis and a ring 22 chromosome. Hybridization was observed on both the normal #22 and the ring 22, indicating that the patient is not constitutionally hemizygous for c-sis. The implications of a ring 22 constitution and the neurofibromatosis phenotype are discussed.

• Authors: A M Duncan, M W Partington, D Soudek
• Journal: Cancer genetics and cytogenetics (Cancer Genet Cytogenet) Vol. 25 Issue 1 Pg. 169-74 (Mar 1987) ISSN: 0165-4608 [Print] United States
• PMID: 3100017 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Genetic Markers

Topics

• Adult
• Chromosome Aberrations
• Chromosomes, Human, Pair 22
• Genetic Markers
• Humans
• Karyotyping
• Lymphocytes (ultrastructure)
• Male
• Neurofibromatosis 1 (genetics)
• Nucleic Acid Hybridization
• Oncogenes
• Ring Chromosomes
• Skin Neoplasms (genetics)