[Antiviral and immunostimulating effect of maleic anhydride copolymers in experimental neuroviral infections].

Abstract

The virus-inhibiting and immunostimulating activity of Soviet preparations, maleic anhydride copolymers, was demonstrated in alpha-, flavi-, and bunyavirus infections. Positive results were obtained in subcutaneous and intraperitoneal inoculations of the preparations used in prophylactic and therapeutic-prophylactic schedules. Stimulation of vaccination immunity was observed after combined use of copolymers and the vaccine against Eastern equine encephalomyelitis.

• Authors: A A Davydova, L L Stotskaia, L K Berezina, L V Osipova, I F Barinskiĭ
• Journal: Voprosy virusologii (Vopr Virusol) 1986 Sep-Oct Vol. 31 Issue 5 Pg. 595-8 ISSN: 0507-4088 [Print] Russia (Federation)
• Vernacular Title: Protivovirusnyĭ i immunostimuliruiushchiĭ éffekt sopolimerov maleinovogo angidrida pri éksperimental'nykh neĭrovirusnykh infektsiiakh.
• PMID: 3099477 (Publication Type: English Abstract, Journal Article)

Chemical References

• Adjuvants, Immunologic
• Antiviral Agents
• Furans
• Maleic Anhydrides
• Polymers
• Viral Vaccines

Topics

• Adjuvants, Immunologic (therapeutic use)
• Animals
• Antiviral Agents (therapeutic use)
• Drug Evaluation, Preclinical
• Drug Therapy, Combination
• Encephalitis Virus, Eastern Equine (immunology)
• Encephalitis Viruses, Tick-Borne (immunology)
• Encephalitis, Tick-Borne (drug therapy, immunology, prevention & control)
• Encephalomyelitis, Equine (drug therapy, immunology, prevention & control)
• Furans (therapeutic use)
• Hemorrhagic Fever Virus, Crimean-Congo (immunology)
• Hemorrhagic Fever, Crimean (drug therapy, immunology, prevention & control)
• Immunity (drug effects)
• Maleic Anhydrides (therapeutic use)
• Mice
• Polymers (therapeutic use)
• Viral Vaccines (therapeutic use)