Rearrangement of immunoglobulin heavy chain genes and T3 expression in the absence of rearrangement of T-cell receptor beta-chain gene in a patient with T-cell malignant lymphoma.

Abstract

We describe the rearrangement of immunoglobulin genes and T3 expression in the absence of rearrangement of T-cell receptor beta-chain genes in a patient with T-cell malignant lymphoma. He had a mediastinal mass and his lymphoma cells expressed T-cell antigens (OKT3+, OKT9+, and OKT10+). When we examined genomic DNA from the lymphoma cells, we detected the rearrangement of immunoglobulin heavy chain genes with a germ-line configuration of light chain genes and no rearrangement of T-cell receptor beta-chain gene. These results indicated that the rearrangement of immunoglobulin genes could occur in T-cell malignant lymphoma, and that T3 antigen could be expressed prior to the rearrangement of T-cell receptor beta-chain genes under certain circumstances.

• Authors: H Ogawa, H Sugiyama, Y Oka, T Maeda, T Komori, Y Tani, S Miyake, T Soma, R Maekura, C Yutani
• Journal: Leukemia research (Leuk Res) Vol. 10 Issue 12 Pg. 1369-75 ( 1986) ISSN: 0145-2126 [Print] England
• PMID: 3099096 (Publication Type: Journal Article)

Chemical References

• Antigens, Differentiation, T-Lymphocyte
• Antigens, Surface
• Immunoglobulin Heavy Chains
• Receptors, Antigen, T-Cell

Topics

• Adult
• Antigens, Differentiation, T-Lymphocyte
• Antigens, Surface (analysis)
• Humans
• Immunoglobulin Heavy Chains (genetics)
• Lymphoma (genetics, immunology)
• Male
• Receptors, Antigen, T-Cell (genetics)
• Recombination, Genetic
• T-Lymphocytes (immunology)