T cell receptor beta chain gene rearrangements in leukemias with immature T cell phenotype.

Abstract

The arrangements of the T cell receptor (TCR) beta genes were studied in leukemias with immature T cell phenotype. Three cases of acute lymphocytic leukemia (ALL) and one case of chronic myelocytic leukemia in blastic crisis (CML-BC), which expressed only Tp40 antigen of cluster of differentiation (CD) 7 without erythrocyte rosette receptor (E), did not show rearrangements of TCR beta chain genes. Two of 5 ALL cases which expressed an additional T cell antigen, T1 of CD5, showed rearrangements of TCR beta genes. Two cases of CML-BC expressing T1 and Tp40, however, had unrearranged TCR beta genes. The results altogether showed that a part of E- T1+ Tp40+ ALL cases is of T cell origin.

• Authors: H Suzuki, R Ueda, Y Obata, M Seto, R Hirata, H Iwamura, K Ota, T Takahashi
• Journal: Japanese journal of cancer research : Gann (Jpn J Cancer Res) Vol. 77 Issue 11 Pg. 1069-73 (Nov 1986) ISSN: 0910-5050 [Print] Japan
• PMID: 3098715 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Receptors, Antigen, T-Cell

Topics

• Blast Crisis (genetics)
• Humans
• Leukemia (genetics, immunology)
• Leukemia, Lymphoid (genetics)
• Leukemia, Myeloid (genetics)
• Phenotype
• Receptors, Antigen, T-Cell (genetics)
• Recombination, Genetic
• T-Lymphocytes (immunology)