Enzyme-linked immunosorbent assay using Mycobacterium tuberculosis antigen 5 for the diagnosis of pulmonary tuberculosis in China.

Abstract

Measurement of serum IgG antibody to Mycobacterium tuberculosis antigen 5 by enzyme-linked immunosorbent assay was evaluated as a serodiagnostic test for pulmonary tuberculosis in China. The test was 89% sensitive and 94 to 100% specific with high accuracies of prediction. Among 82 tuberculous patients, antibody titer was related to the extent of pulmonary disease. Among control subjects, false positive tests were encountered among 5 of 52 persons with other pulmonary disease and not among 30 healthy subjects. The characteristics of this test compare favorably with those reported for sputum smear examination.

• Authors: Y Ma, Y M Wang, T M Daniel
• Journal: The American review of respiratory disease (Am Rev Respir Dis) Vol. 134 Issue 6 Pg. 1273-5 (Dec 1986) ISSN: 0003-0805 [Print] United States
• PMID: 3098148 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antibodies, Bacterial
• Antigens, Bacterial
• Immunoglobulin G

Topics

• Antibodies, Bacterial (analysis)
• Antigens, Bacterial (immunology)
• China
• Enzyme-Linked Immunosorbent Assay
• Evaluation Studies as Topic
• False Positive Reactions
• Humans
• Immunoglobulin G (analysis)
• Mycobacterium tuberculosis (immunology)
• Serologic Tests (methods)
• Silicotuberculosis (diagnosis)
• Tuberculosis, Pulmonary (diagnosis)