[Dynamics of the contamination of mice during the treatment of burn sepsis due to Pseudomonas aeruginosa using tobramycin alone or combined with active and passive immunization].

Abstract

An experimental study was made with a view to finding out the possible bacteriological advantages of the combined use of tobramycin (Tb) and P. aeruginosa corpuscular polyvalent vaccine (PaCPV) or P. aeruginosa hyperimmune plasma (PaHIP) in burn sepsis caused by P. aeruginosa. The use of the median therapeutic dose of Tb (2.5 mg/kg body weight per day), alone or in combination with immunopreparations, ensured the survival rate of the animals equal to 100%. The contamination of the body with P. aeruginosa after treatment with Tb and PaHIP or PaCPV was lower than after the administration of Tb alone, this phenomenon becoming manifest starting from day 5 of observation in the first case and from day 10 in the second case. The combined use of Tb and immunopreparations (PaCPV or PaHIP) in acute P. aeruginosa infection proved to be more effective than treatment with Tb alone.

• Authors: V V Minukhin, A Ia Tsyganenko
• Journal: Zhurnal mikrobiologii, epidemiologii i immunobiologii (Zh Mikrobiol Epidemiol Immunobiol) Issue 9 Pg. 90-2 (Sep 1986) ISSN: 0372-9311 [Print] Russia (Federation)
• Vernacular Title: Dinamika obsemenennosti mysheĭ pri lechenii ozhogovogo sepsisa, obuslovlennogo Pseudomonas aeruginosa, tol'ko tobramitsinom ili v sochetanii s aktivnoĭ i passivnoĭ immunizatsieĭ.
• PMID: 3098009 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Bacterial Vaccines
• Tobramycin

Topics

• Animals
• Bacterial Vaccines (therapeutic use)
• Burns (complications, microbiology, therapy)
• Combined Modality Therapy
• Drug Evaluation, Preclinical
• Immunization
• Immunization, Passive
• Mice
• Pseudomonas Infections (microbiology, mortality, therapy)
• Pseudomonas aeruginosa (immunology)
• Tobramycin (therapeutic use)