HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Acute effects of marihuana smoking on maximal exercise performance.

Abstract
To evaluate the effects of marihuana smoking on exercise performance, 12 healthy young subjects did progressive exercise testing on an ergocycle to exhaustion under two conditions: non-smoking (control) and 10 min after smoking a marihuana cigarette (containing 1.7% of delta-9-tetra-hydro-cannabinol) of 7 mg X kg-1 body weight. Heart rate, arterial blood pressure, minute ventilation (VE), breathing rate (fb), oxygen uptake (VO2), and carbon dioxide output (VCO2) were measured before, during, and for 4 min after the exercise. Tidal volume was calculated from VE X fb-1. The exercise duration was also measured. Forced expiratory volume (FEV1) was measured: before smoking (rest); before exercise (10 min after smoking); and after exercise. Carboxyhemoglobin levels were measured before and 10 min after smoking in four subjects. Marihuana smoking reduced exercise duration (16.1 +/- 4.0 to 15.1 +/- 3.3 min, P less than 0.05). At peak exercise performance, there were no differences in VO2, VCO2, heart rate, and VE between the two experimental conditions. Marihuana induced tachycardia at preexercise (94.3 +/- 13.3 beats X min-1 to 119.0 +/- 18.0, P less than 0.01) that was sustained up to 80% of maximum effort and during the recovery period. After marihuana, VE, VO2 and VCO2 were increased above control from 50% of maximum effort to the end of the test. Marihuana induced a bronchodilation (FEV1 from 4.28 +/- 1.00 to 4.43 +/- 1.031, P less than 0.0) that was still present after exercise. Exercise induced a bronchodilation in the control condition but not in the marihuana smoking condition.(ABSTRACT TRUNCATED AT 250 WORDS)
AuthorsA M Renaud, Y Cormier
JournalMedicine and science in sports and exercise (Med Sci Sports Exerc) Vol. 18 Issue 6 Pg. 685-9 (Dec 1986) ISSN: 0195-9131 [Print] UNITED STATES
PMID3097453 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Carbon Dioxide
Topics
  • Adult
  • Blood Pressure
  • Bronchi (physiopathology)
  • Carbon Dioxide (metabolism)
  • Dilatation, Pathologic (etiology)
  • Energy Metabolism
  • Female
  • Heart Rate
  • Humans
  • Male
  • Marijuana Abuse (complications, physiopathology)
  • Oxygen Consumption
  • Physical Exertion
  • Respiratory Function Tests
  • Tachycardia (etiology)
  • Work Capacity Evaluation

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: