Determination of in vivo concentration-time profiles of chlorhexidine and noxythiolin bladder irrigations.

Abstract

The in vivo concentration-time profiles of chlorhexidine and noxythiolin bladder irrigations were determined by utilizing high-performance liquid chromatography techniques following a once daily irrigation. A total of 14 chlorhexidine irrigations established a mean concentration of 0.006% w/v, 2-3 h post irrigation. A total of 12 noxythiolin irrigations established a mean concentration of 0.266% w/v, 2-3 h post irrigation, which correlated to a mean formaldehyde concentration of 0.0119% w/v at 2-3 h, as estimated from N-methylthiourea. For both solutions the minimum inhibitory concentration was exceeded for up to 5 h post irrigation, which is sufficient contact time to establish a total kill, thus indicating the possibility that a once daily irrigation may be appropriate in asymptomatic bacteriuria which utilizes either chlorhexidine or noxythiolin.

• Authors: W N Cottrell, R W Fitzpatrick
• Journal: Journal of clinical and hospital pharmacy (J Clin Hosp Pharm) Vol. 11 Issue 5 Pg. 335-42 (Oct 1986) ISSN: 0143-3180 [Print] England
• PMID: 3097078 (Publication Type: Journal Article)

Chemical References

• Noxythiolin
• Thiourea
• Chlorhexidine

Topics

• Aged
• Bacteriuria (metabolism)
• Chlorhexidine (urine)
• Chromatography, High Pressure Liquid
• Humans
• Noxythiolin (urine)
• Therapeutic Irrigation
• Thiourea (analogs & derivatives)
• Urinary Bladder (drug effects, metabolism)