Sodium ferulate inhibits myocardial hypertrophy induced by abdominal coarctation in rats: Involvement of cardiac PKC and MAPK signaling pathways.

Abstract

Sodium ferulate (SF) is the sodium salt of ferulic acid which is an active ingredient of Radix Angelica Sinensis and Ligusticum chuanxiong hort. Here, we investigated SF inhibition in a rat model of myocardial hypertrophy induced by coarctation of the abdominal aorta. Following coarctation, rats were given SF (20, 40, and 80 mg/kg/day) for 25 consecutive days. We characterized myocardial hypertrophy using myocardial hypertrophic parameters, histopathology, and gene expression of atrial natriuretic factor (ANF) -a gene related to myocardial hypertrophy. We detected the levels of angiotensin II (Ang II) and endothelin-1 (ET-1), protein kinase C beta (PKC-β), Raf-1, extracellular regulated protein kinase 1/2 (ERK1/2), and mitogen-activated protein kinase phosphatase-1 (MKP-1) in myocardium. Notably, coarctation of the abdominal aorta increases myocardial hypertrophic parameters, cardiac myocyte diameter, the concentration of Ang II and ET-1 in myocardium, and gene expression of ANF. SF significantly ameliorates myocardial hypertrophy caused by coarctation of the abdominal aorta; reduces concentrations of Ang II and ET-1; suppresses the overexpression of ANF, PKC-β, Raf-1, and ERK1/2; and increases the expression of MKP-1. These results indicate that SF alleviates myocardial hypertrophy induced by coarctation of the abdominal aorta, and these protective effects could be related to the inhibition of PKC and mitogen-activated protein kinase (MAPK) signaling pathways.

• Authors: Min Luo, Pan-Pan Chen, Lu Yang, Peng Wang, Yan-Liu Lu, Fu-Guo Shi, Yang Gao, Shang-Fu Xu, Qi-Hai Gong, Rui-Xia Xu, Jiang Deng
• Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (Biomed Pharmacother) Vol. 112 Pg. 108735 (Apr 2019) ISSN: 1950-6007 [Electronic] France
• PMID: 30970525 (Publication Type: Journal Article)
• Copyright: Copyright © 2019 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Chemical References

• Coumaric Acids
• ferulic acid
• Protein Kinase C

Topics

• Animals
• Aorta, Abdominal (pathology)
• Aortic Coarctation (complications)
• Cardiomegaly (drug therapy, etiology, metabolism, pathology)
• Coumaric Acids (administration & dosage, therapeutic use)
• Dose-Response Relationship, Drug
• Hemodynamics (drug effects)
• MAP Kinase Signaling System (drug effects)
• Male
• Myocardium (enzymology, pathology)
• Protein Kinase C (metabolism)
• Rats, Sprague-Dawley