Huang Qi Tong Bi Decoction Attenuates Myocardial Ischemia-Reperfusion Injury via HMGB1/TLR/NF-κB Pathway.

Abstract

The aim of this study was to study the protective effect of Huang Qi Tong Bi Decoction (HQTBT) on the heart of rats. Ischemia-reperfusion injury was established by coronary artery ligation. Proinflammatory cytokines were decreased by XFZY in coronary artery ligated rats. ST segment was also restored with the treatment of HQTBT. Triphenyltetrazole chloride (TTC) staining and pathological analysis showed that HQTBT reduced myocardial injury. Besides, the expressions of HMGB1/TLR/NF-κB pathway in rats were significantly decreased by HQTBT. This study shows that HQTBT inhibited inflammatory reaction on myocardial injury in rats.

• Authors: Kun Liu, Manman Li, Xiumei Ren, Qing-Sheng You, Fei Wang, Shuo Wang, Chun-Hui Ma, Wei-Nan Li, Qing Ye
• Journal: Mediators of inflammation (Mediators Inflamm) Vol. 2019 Pg. 8387636 ( 2019) ISSN: 1466-1861 [Electronic] United States
• PMID: 30944548 (Publication Type: Journal Article)

Chemical References

• Drugs, Chinese Herbal
• HMGB1 Protein
• NF-kappa B
• Toll-Like Receptors
• Huang Qi

Topics

• Animals
• Astragalus propinquus
• Drugs, Chinese Herbal (therapeutic use)
• HMGB1 Protein (metabolism)
• Male
• Myocardial Reperfusion Injury (drug therapy, metabolism)
• NF-kappa B (metabolism)
• Rats
• Rats, Sprague-Dawley
• Signal Transduction (drug effects, physiology)
• Toll-Like Receptors (metabolism)