Abstract |
This study investigates the effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on persistent post-concussion syndrome (PCS). The study design was a randomized (coin toss), placebo controlled, and double-blind study. Thirty-seven participants with PCS were assessed for eligibility; 22 were randomised and 18 completed the study requirements. Half the participants with PCS were given an Active rTMS intervention and the other half given Sham rTMS over 3 weeks. Follow ups were at the end of treatment and at 30 and 60 days. The primary outcome measure was the Rivermead Post-Concussion Symptoms Questionnaire (RPQ3 & RPQ13). The results indicate participants with more recent injuries (<12 month), who received Active rTMS, showed significant improvements compared to those of: 1) the same subgroup who received Sham, and 2) those with a longer duration of injury (>14 months) who received Active rTMS. This improvement predominantly manifested in RPQ13 in the follow up periods 1 and 2 months after the intervention (RPQ13 change (mean ± SD): at 1 month, Active = -21.8 ± 6.6, Sham = -2.2 ± 9.8; at 2 months, Active = -21.2 ± 5.3, Sham = -5.4 ± 13.7). No improvement was found in the subgroup with longer duration injuries. The results support rTMS as a tolerable and potentially effective treatment option for individuals with a recent (<1 year) concussion.
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Authors | Zahra Moussavi, Abdelbaset Suleiman, Grant Rutherford, Omid Ranjbar Pouya, Zeinab Dastgheib, Weijia Zhang, Jennifer Salter, Xikui Wang, Behzad Mansouri, Brian Lithgow |
Journal | Scientific reports
(Sci Rep)
Vol. 9
Issue 1
Pg. 5498
(04 02 2019)
ISSN: 2045-2322 [Electronic] England |
PMID | 30940870
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Double-Blind Method
- Female
- Humans
- Male
- Middle Aged
- Pilot Projects
- Post-Concussion Syndrome
(therapy)
- Time Factors
- Transcranial Magnetic Stimulation
(adverse effects, methods)
- Treatment Outcome
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