[Positive effects of L-dopa on a "marginal" symptomatology observed in parkinsonians].

Abstract

In some patients with parkinsonism, we have found and, often, cured by L-DOPA: 1) An unfrequent symptomatology (oculomotor, sensory, syncinesias, "Babinski" sign), not included in the classic rating scales. 2) A symptomatology "attributable to frontal lesion": grasping; inability to reproduce a serie of three gestures; inability to react to an audio-visual stimulus by a definited opposite gesture. In such patients, the improvement is in total contrast with the lack of effect of L-DOPA in several patients with frontal lesions, but without parkinsonism. It is possible that the last constatation may contribute: a) to localize more exactly the topography of dopaminergic pathways, b) to approach the respective parts of the cortical and subcortical structures in the programming of the movement.

• Authors: A Morel-Maroger
• Journal: L'Encephale (Encephale) Vol. 4 Issue 3 Pg. 223-31 ( 1978) ISSN: 0013-7006 [Print] France
• Vernacular Title: Effets positifs de la L-dopa sur une symptomatologie "marginale" observée chez les parkinsoniens.
• PMID: 309387 (Publication Type: Case Reports, Comparative Study, English Abstract, Journal Article)

Chemical References

• Levodopa

Topics

• Aged
• Brain Diseases (complications)
• Female
• Frontal Lobe
• Humans
• Levodopa (therapeutic use)
• Male
• Ophthalmoplegia (drug therapy)
• Paresthesia (drug therapy)
• Parkinson Disease, Secondary (diagnosis, drug therapy, etiology)
• Reflex, Babinski