Serum amylase activity altered by the ABO blood group system in Chinese subjects.

Abstract

OBJECTIVE:

The underlying interactions between ABO blood group antigens and pancreatic exocrine tissue have been demonstrated, and serum amylase was synthesized by pancreatic ductal cells. Thus, we investigated the link between ABO blood type and serum amylase activity in Chinese subjects.

METHODS:

Our study included 343 relatively healthy Chinese individuals, and the data were retrieved from electronic medical record database.

RESULTS:

A increased trend was observed for serum amylase activity in ABO blood type distribution, and we found that serum amylase activity was remarkable increased in subjects with O blood type compared to those with non-O blood type (P = 0.013). Logistic regression analysis indicated that serum amylase was independently associated with individuals with O blood group (adjusted odds ratio 1.574; 95% CI, 1.022-2.425, P = 0.039).

CONCLUSIONS:

The present evidence suggests a significant link between serum amylase activity and ABO blood type in the study population, indicating ABO blood type may be associated with the susceptibility of pancreatic disease.

• Authors: You-Fan Peng, Hemant Goyal, Hao Lin, De-Chen Liu, Ling Li
• Journal: Journal of clinical laboratory analysis (J Clin Lab Anal) Vol. 33 Issue 5 Pg. e22883 (Jun 2019) ISSN: 1098-2825 [Electronic] United States
• PMID: 30938472 (Publication Type: Journal Article)
• Copyright: © 2019 The Authors. Journal of Clinical Laboratory Analysis Published by Wiley Periodicals, Inc.

Chemical References

• ABO Blood-Group System
• Amylases
• Pancreatic alpha-Amylases

Topics

• ABO Blood-Group System (metabolism)
• Adolescent
• Adult
• Amylases (blood)
• Asian People
• Female
• Humans
• Logistic Models
• Male
• Middle Aged
• Pancreatic alpha-Amylases (blood)
• Retrospective Studies