The influence of hemoglobin level on the regression and long term local control of transitional cell carcinoma of the bladder following photon irradiation.

Abstract

Patients with transitional cell carcinoma of the bladder treated by radical megavoltage X ray therapy are analyzed. There was a significant correlation between tumor T stage classification and the hemoglobin level at the start of radical radiotherapy. A hemoglobin level of 12g/dl or more was associated with a significant improvement in complete local tumor regression at 6 months and durable local tumor control for patients with T3 cancer or a cancer of grade 3 histology. Hemoglobin level did not influence survival for patients with T1 or grade 1 cancer. Those patients with T2-T4 cancer, grade 2-3 cancer, or a cancer of solid or mixed appearance had a significantly better survival probability if their hemoglobin level was more than 13g/dl. Hemoglobin level would appear to exert its influence on survival by an effect on local tumor control. It has no significant independent effect on the hazard of distant metastases.

• Authors: P M Quilty, W Duncan
• Journal: International journal of radiation oncology, biology, physics (Int J Radiat Oncol Biol Phys) Vol. 12 Issue 10 Pg. 1735-42 (Oct 1986) ISSN: 0360-3016 [Print] United States
• PMID: 3093414 (Publication Type: Journal Article)

Chemical References

• Hemoglobins

Topics

• Carcinoma, Transitional Cell (blood, radiotherapy)
• Female
• Hemoglobins (analysis)
• Humans
• Male
• Prognosis
• Radiotherapy, High-Energy
• Urinary Bladder Neoplasms (blood, radiotherapy)