Abstract | PURPOSE: PATIENTS AND METHODS: RESULTS: Four hundred thirty-six patients with ESCC in six centers were recruited at a 1:1 ratio between April 2012 and July 2015. The median follow-up of the surviving patients was 48.7 months (interquartile range, 42.6-60.9). The 3-year OS was 55.4% in the paclitaxel plus fluorouracil group and 51.8% in the cisplatin plus fluorouracil group (hazard ratio, 0.905 [95% CI, 0.698 to 1.172]; P = .448). The 3-year progression-free survival was also not significantly different between the paclitaxel plus fluorouracil group and the cisplatin plus fluorouracil group (43.7% v 45.5%, respectively; hazard ratio, 0.973 [95% CI, 0.762 to 1.243]; P = .828). Compared with the cisplatin plus fluorouracil group, the paclitaxel plus fluorouracil group had significantly lower incidences of acute grade 3 or higher anemia, thrombocytopenia, anorexia, nausea, vomiting, and fatigue (P < .05), but higher incidences of acute grade 3 or higher leukopenia, radiation dermatitis, and radiation pneumonitis (P < .05). CONCLUSION:
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Authors | Yun Chen, Jinjun Ye, Zhengfei Zhu, Weixin Zhao, Jialiang Zhou, Chaoyang Wu, Huarong Tang, Min Fan, Ling Li, Qin Lin, Yi Xia, Yunhai Li, Jiancheng Li, Huixun Jia, Saiquan Lu, Zhen Zhang, Kuaile Zhao |
Journal | Journal of clinical oncology : official journal of the American Society of Clinical Oncology
(J Clin Oncol)
Vol. 37
Issue 20
Pg. 1695-1703
(07 10 2019)
ISSN: 1527-7755 [Electronic] United States |
PMID | 30920880
(Publication Type: Clinical Trial, Phase III, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Paclitaxel
- Cisplatin
- Fluorouracil
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Topics |
- Adolescent
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage)
- Carcinoma, Squamous Cell
(therapy)
- Chemoradiotherapy
- China
- Cisplatin
(administration & dosage)
- Consolidation Chemotherapy
- Disease-Free Survival
- Esophageal Neoplasms
(therapy)
- Fluorouracil
(administration & dosage)
- Humans
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Paclitaxel
(administration & dosage)
- Photons
- Proportional Hazards Models
- Treatment Outcome
- Young Adult
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