Abstract | PURPOSE: METHODS: RESULTS: PDN rats demonstrated a marked tactile allodynia with no thermal hyperalgesia whilst non-PDN rats exhibited a prominent hypo-responsiveness towards non-noxious stimuli and hypoalgesia towards thermal input. The MDA level and pro-inflammatory TNF-α was significantly increased in PDN rats whilst catalase was reduced in these rats. Meanwhile, non-PDN rats demonstrated reduced SOD enzyme activity and TNF-α level and increased MDA and catalase activity. CONCLUSION: The changes in oxidative stress parameters and pro-inflammatory factors may contribute to the changes in behavioural responses in both PDN and non-PDN rats.
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Authors | Che Aishah Nazariah Ismail, Che Badariah Abd Aziz, Rapeah Suppian, Idris Long |
Journal | Journal of diabetes and metabolic disorders
(J Diabetes Metab Disord)
Vol. 17
Issue 2
Pg. 129-136
(Dec 2018)
ISSN: 2251-6581 [Print] Switzerland |
PMID | 30918846
(Publication Type: Journal Article)
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