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[Congestive cardiomyopathy in addiction to clobenzorex, an anorexigenic drug].

Abstract
Cardiac failure caused by high doses of amphetamine-like drugs is rare. We report a case of decompensated congestive cardiomyopathy occurring in a 29 year old woman addicted to clobenzorex (Dinintel). This patient had been taking 5 to 7 capsules per day for 5 years. No other cause of cardiac failure was detected. A rapid improvement was obtained by digitalis and diuretic therapy; no further episodes of cardiac failure were observed after one year. However, the drug could not be completely withdrawn and echocardiography has shown increasing left ventricular dilatation. The possible mechanisms of amphetamine induced myocardial toxicity are discussed and the analogy with the group of adrenergic cardiomyopathies is underlined.
AuthorsP Cornaert, J Camblin, P Graux, B Anaye, A Dutoit, L Croccel
JournalArchives des maladies du coeur et des vaisseaux (Arch Mal Coeur Vaiss) Vol. 79 Issue 4 Pg. 515-8 (Apr 1986) ISSN: 0003-9683 [Print] France
Vernacular TitleCardiomyopathie congestive au cours d'une toxicomanie à un anorexigène, le clobenzorex.
PMID3090971 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Amphetamines
  • clobenzorex
Topics
  • Adult
  • Amphetamines (adverse effects)
  • Cardiomyopathy, Dilated (chemically induced, physiopathology)
  • Female
  • Humans
  • Prognosis
  • Substance-Related Disorders (complications)

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