Anatolicin, a Highly Potent and Selective Cytotoxic Sesquiterpene Coumarin from the Root Extract of Heptaptera anatolica.

Abstract

Seven known sesquiterpene coumarins and a new sesquiterpene coumarin, anatolicin (8), were isolated from the dichloromethane extract of the roots of Heptaptera anatolica. Structures of these compounds were elucidated based on their spectral properties. While some of these sesquiterpene coumarins showed modest cytotoxic activity against COLO205, KM12, A498, UO31, and TC32 cancer cell lines, selective cytotoxicity of anatolicin (8) and 14'-acetoxybadrakemin (7) were observed at nanomolar level against the UO31 kidney cancer cell line.

• Authors: Fatma Tosun, John A Beutler, Tanya T Ransom, Mahmut Miski
• Journal: Molecules (Basel, Switzerland) (Molecules) Vol. 24 Issue 6 (Mar 23 2019) ISSN: 1420-3049 [Electronic] Switzerland
• PMID: 30909537 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Coumarins
• Plant Extracts
• Sesquiterpenes
• coumarin

Topics

• Antineoplastic Agents, Phytogenic (chemistry, pharmacology)
• Apiaceae (chemistry)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Coumarins (chemistry, pharmacology)
• Humans
• Kidney Neoplasms (drug therapy)
• Molecular Structure
• Plant Extracts (chemistry, pharmacology)
• Plant Roots (chemistry)
• Sesquiterpenes (chemistry, pharmacology)