Successful therapy of penicillinase-producing Neisseria gonorrhoeae pharyngeal infection during pregnancy.

Abstract

The relative frequency of pharyngeal gonococcal infection may be increased in certain prenatal populations. Therapy of penicillin-sensitive strains of Neisseria gonorrhoeae is associated with acceptable cure rates using aqueous procaine penicillin with probenecid. Infection of the oropharynx of pregnant women with penicillinase-producing strains is more problematic. The antibiotics normally used for the therapy of uncomplicated penicillinase-producing N gonorrhoeae infections, spectinomycin or cefoxitin, are not effective in the therapy of pharyngeal infection. Reported is the first case of penicillinase-producing N gonorrhoeae oropharyngeal infection during pregnancy. The patient was successfully treated with trimethoprim/sulfamethoxazole, and no maternal or neonatal morbidity was noted.

• Authors: D E Soper, S Merrill-Nach
• Journal: Obstetrics and gynecology (Obstet Gynecol) Vol. 68 Issue 2 Pg. 290-1 (Aug 1986) ISSN: 0029-7844 [Print] United States
• PMID: 3090494 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Drug Combinations
• Trimethoprim, Sulfamethoxazole Drug Combination
• Trimethoprim
• Penicillinase
• Sulfamethoxazole

Topics

• Adult
• Anti-Bacterial Agents (therapeutic use)
• Drug Combinations (therapeutic use)
• Female
• Gonorrhea (drug therapy)
• Humans
• Infant, Newborn
• Neisseria gonorrhoeae (enzymology)
• Penicillinase (metabolism)
• Pharyngitis (drug therapy, etiology)
• Pregnancy
• Pregnancy Complications, Infectious (drug therapy)
• Sulfamethoxazole (therapeutic use)
• Trimethoprim (therapeutic use)
• Trimethoprim, Sulfamethoxazole Drug Combination