Wound closure and follow-up after total knee arthroplasty - Do they affect the rate of antibiotic prescription?

Abstract

BACKGROUND:

This study aimed to evaluate risk factors for oral antibiotic prescription in the first six weeks after primary TKA, particularly whether the wound closure method (staples or sutures) and two-week follow-up clinician (surgeon or general practitioner (GP)) altered antibiotic use.

METHODS:

Four thousand eight hundred forty-six TKAs from January 2013 to December 2016 at three tertiary hospitals in Auckland, New Zealand were analysed by manual review of patient electronic records and a national prescription database. Surgeon preference dictates the method of wound closure and whether wound review is followed up by the operating surgeon or by the patient's GP. Univariate and multivariate analysis was carried out to identify significant patient and surgical risk factors for oral antibiotic prescribing.

RESULTS:

Oral antibiotics were prescribed in 24% of patients following primary TKA. Twenty-six percent of patients closed with staples were prescribed oral antibiotics versus 19% with sutures (adjusted OR = 1.4, p < 0.004). Excluding re-presentations and readmissions, GPs prescribed oral antibiotics in 22% of patients compared to seven percent of patients seen by surgeons (adjusted OR = 2.8, p < 0.001). Other risk factors for antibiotic prescription included increasing age, BMI and ASA score.

CONCLUSION:

Oral antibiotic prescribing rates are higher if the wound was closed with staples and if a GP performed the two-week follow-up. Improved communication between surgeons and GPs are required to ensure adequate follow-up following TKA and appropriate oral antibiotic use.

• Authors: Mark Zhu, Richard Rahardja, Jacob Munro, Brendan Coleman, Simon W Young
• Journal: The Knee (Knee) Vol. 26 Issue 3 Pg. 700-707 (Jun 2019) ISSN: 1873-5800 [Electronic] Netherlands
• PMID: 30904322 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2019. Published by Elsevier B.V.

Chemical References

• Anti-Bacterial Agents

Topics

• Adolescent
• Adult
• Age Factors
• Aged
• Aged, 80 and over
• Anti-Bacterial Agents (therapeutic use)
• Arthroplasty, Replacement, Knee
• Body Mass Index
• Child
• Drug Prescriptions (statistics & numerical data)
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• New Zealand
• Risk Factors
• Surgical Stapling
• Surgical Wound Infection (drug therapy)
• Sutures
• Young Adult