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Evaluation of misoprostol cytoprotection of the bladder with cyclophosphamide (Cytoxan) therapy.

Abstract
Cyclophosphamide is a well established cytotoxic drug used in the treatment of lymphoproliferative disorders, certain solid tumors, and nonneoplastic disorders such as nephrotic syndrome, systemic lupus erythematosus and rheumatoid arthritis. Hemorrhagic cystitis can be a complication of this drug varying between two and 40 per cent. Misoprostol, which is a synthetic prostaglandin E1 analog, was found to significantly decrease the histological damage to the bladder from cyclophosphamide. Male rats receiving misoprostol in conjunction with cyclophosphamide were found to have a reduction in ulceration, inflammation and edema of the bladder walls as compared to those treated with cyclophosphamide alone.
AuthorsK J Gray, U H Engelmann, E H Johnson, I J Fishman
JournalThe Journal of urology (J Urol) Vol. 136 Issue 2 Pg. 497-500 (Aug 1986) ISSN: 0022-5347 [Print] United States
PMID3090278 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Misoprostol
  • Cyclophosphamide
  • Alprostadil
Topics
  • Alprostadil (analogs & derivatives, pharmacology, therapeutic use)
  • Animals
  • Cyclophosphamide (toxicity)
  • Cystitis (chemically induced, prevention & control)
  • Hemorrhage (chemically induced, prevention & control)
  • Male
  • Misoprostol
  • Mucous Membrane (drug effects)
  • Organ Size (drug effects)
  • Rats
  • Rats, Inbred Strains
  • Urinary Bladder (drug effects)
  • Urinary Bladder Diseases (chemically induced, prevention & control)

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