Modulation of phorbol ester receptors in mouse skin by application of quercetin.

Abstract

The topical application of quercetin, an anti-tumor promoter, to mouse skin reduced the number of phorbol ester receptors, although quercetin did not inhibit specific 3H-12-O-tetradecanoylphorbol-13-acetate binding to a mouse skin particulate fraction. Quercetin, morin, kaempferol and luteolin inhibited activation of protein kinase C by teleocidin, and caused half-maximal activation at 25 microM. (+)-Catechin, which has been reported not to inhibit tumor-promoting activity, did not have any effect on these reactions. The modulation of phorbol ester receptors and inhibition of activation of protein kinase C are considered to be involved in the anti-tumor-promoting effect of quercetin in mouse skin. Diet containing 4% or 1% quercetin did not influence the action of teleocidin on mouse skin in a two-stage carcinogenesis experiment.

• Authors: T Horiuchi, H Fujiki, H Hakii, M Suganuma, K Yamashita, T Sugimura
• Journal: Japanese journal of cancer research : Gann (Jpn J Cancer Res) Vol. 77 Issue 6 Pg. 526-31 (Jun 1986) ISSN: 0910-5050 [Print] Japan
• PMID: 3089985 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Caenorhabditis elegans Proteins
• Carrier Proteins
• Flavonoids
• Lyngbya Toxins
• Receptors, Drug
• Receptors, Immunologic
• phorbol ester binding protein
• phorbol ester receptor
• Tritium
• teleocidins
• Quercetin
• Protein Kinase C
• Tetradecanoylphorbol Acetate

Topics

• Animals
• Caenorhabditis elegans Proteins
• Carrier Proteins
• Flavonoids (pharmacology)
• Lyngbya Toxins (pharmacology)
• Mice
• Mice, Inbred Strains
• Protein Kinase C (analysis)
• Quercetin (metabolism, pharmacology)
• Receptors, Drug
• Receptors, Immunologic (drug effects)
• Skin (analysis, drug effects)
• Skin Neoplasms (chemically induced, prevention & control)
• Tetradecanoylphorbol Acetate (metabolism)
• Tritium