New era of research on cancer-associated glycosphingolipids.

Abstract

Cancer-associated glycosphingolipids have been used as markers for diagnosis and targets for immunotherapy of malignant tumors. Recent progress in the analysis of their implications in the malignant properties of cancer cells revealed that cancer-associated glycosphingolipids are not only tumor markers, but also functional molecules regulating various signals introduced by membrane microdomains, lipid rafts. In particular, a novel approach, enzyme-mediated activation of radical sources combined with mass spectrometry, has enabled us to clarify the mechanisms by which cancer-associated glycosphingolipids regulate cell signals based on the interaction with membrane molecules and formation of molecular complexes on the cell surface. Novel findings obtained from these approaches are now providing us with insights into the development of new anticancer therapies targeting membrane molecular complexes consisting of cancer-associated glycolipids and their associated membrane molecules. Thus, a new era of cancer-associated glycosphingolipids has now begun.

• Authors: Koichi Furukawa, Yuhsuke Ohmi, Yuki Ohkawa, Robiul H Bhuiyan, Pu Zhang, Orie Tajima, Noboru Hashimoto, Kazunori Hamamura, Keiko Furukawa
• Journal: Cancer science (Cancer Sci) Vol. 110 Issue 5 Pg. 1544-1551 (May 2019) ISSN: 1349-7006 [Electronic] England
• PMID: 30895683 (Publication Type: Journal Article, Review)
• Copyright: © 2019 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

Chemical References

• Biomarkers, Tumor
• Glycosphingolipids

Topics

• Animals
• Biomarkers, Tumor (metabolism)
• Cell Membrane (metabolism)
• Glycosphingolipids (metabolism)
• Humans
• Mass Spectrometry
• Neoplasms (metabolism)
• Signal Transduction