Abstract |
The authors describe two patients with clinically and histopathologically documented advanced ( tumor) stage mycosis fungoides. In each case the large, pleomorphic neoplastic cells lacked the monoclonal antibody-defined cell surface antigens commonly associated with immature and mature T-cells, i.e., T11, Leu-1, T3, T4, T6, T8, and T10, but expressed various T-cell-associated activation antigens, such as HLA-DR, Tac, and T21. Leu-M1, a monocyte-associated antigen, was not expressed by the small, cerebriform neoplastic cells in the plaque stage lesions of either patient. However, Leu-M1 was expressed by most of the large, pleomorphic neoplastic cells present in the nodular lesions of both patients. The pattern of Leu-M1 antigen expression was identical to that previously reported in the Reed-Sternberg cells of Hodgkin's disease. Identification of these two patients suggests using caution in the interpretation of the results of immunophenotypic analysis of cutaneous lymphoid neoplasms and that Leu-M1 should not be used as a diagnostic indicator of Hodgkin's disease or a histiocytic-derived neoplasm. These studies also suggest that Leu-M1 may be preferentially expressed on a subpopulation of activated, rapidly proliferating, and/or dedifferentiated neoplastic T-cells that proliferate in the advanced ( tumor) stages of mycosis fungoides.
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Authors | R Wieczorek, M Suhrland, D Ramsay, M L Reed, D M Knowles 2nd |
Journal | American journal of clinical pathology
(Am J Clin Pathol)
Vol. 86
Issue 1
Pg. 25-32
(Jul 1986)
ISSN: 0002-9173 [Print] England |
PMID | 3088980
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antibodies, Monoclonal
- Antigens, Differentiation, T-Lymphocyte
- Antigens, Neoplasm
- Antigens, Surface
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Topics |
- Aged
- Antibodies, Monoclonal
- Antigens, Differentiation, T-Lymphocyte
- Antigens, Neoplasm
(analysis)
- Antigens, Surface
(analysis)
- Female
- Fluorescent Antibody Technique
- Humans
- Immunoenzyme Techniques
- Male
- Microscopy, Electron
- Middle Aged
- Mycosis Fungoides
(immunology, pathology)
- Phenotype
- Skin
(ultrastructure)
- Skin Neoplasms
(immunology, pathology)
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