The effect of lipoxygenase inhibitors and leukotriene antagonists on anaphylaxis.

Abstract

The experiments whose results are reported here were carried out with the aim of showing a possible role for lipoxygenase products in the modulation of the Schultz-Dale reaction. For this purpose, the actions of nordihydroguaieretic acid (NDGA) and of FPL 55712 were tested during anaphylaxis in guinea-pig ileum and trachea in vitro. Isolated preparations from guinea-pigs, which had been subcutaneously sensitized with ovalbumin and incomplete Freund adjuvant, were challenged with increasing concentrations of antigen; in preparations isolated from the same animal an antigen-concentration anaphylactic-reaction curve was performed in the presence of the drugs. NDGA 3.3 X 10(-6) M was capable of inhibiting anaphylaxis in the trachea to a maximum extent of 40% but it did not affect anaphylactic reaction in the intestinal smooth muscle. FPL 55712 2 X 10(-6) M did not exert any activity on anaphylaxis in either preparations. The difference between SRS-A and histamine as mediators of anaphylaxis in the tissue preparations used could explain the fact that NDGA acted on the trachea alone.

• Authors: S Franchi-Micheli, S Luzzi, M Ciuffi, L Zilletti
• Journal: Agents and actions (Agents Actions) Vol. 18 Issue 1-2 Pg. 242-4 (Apr 1986) ISSN: 0065-4299 [Print] Switzerland
• PMID: 3088925 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Catechols
• Chromones
• Lipoxygenase Inhibitors
• SRS-A
• Masoprocol
• FPL 55712

Topics

• Anaphylaxis (prevention & control)
• Animals
• Catechols (pharmacology)
• Chromones (pharmacology)
• Guinea Pigs
• Ileum (drug effects)
• In Vitro Techniques
• Lipoxygenase Inhibitors
• Male
• Masoprocol
• SRS-A (antagonists & inhibitors)
• Trachea (drug effects)