HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Comparison of the efficacy of subcutaneous and nasal spray buserelin treatment in suppression of testicular steroidogenesis in men with prostate cancer.

Abstract
The comparative efficacy of subcutaneous injections and intranasal spray in the maintenance of suppression of testicular function in men with advanced prostatic cancer treated with a gonadotropin-releasing hormone (GnRH) agonist, Buserelin, was evaluated in a nonrandomized clinical trial. After a common induction period of 1 week's treatment with 500 micrograms three times daily by subcutaneous injection, patients were allocated into one of two groups for maintenance therapy with either subcutaneous (200 micrograms once daily) or intranasal (400 micrograms nasal spray three times daily) Buserelin therapy. Plasma luteinizing hormone (LH) and sex steroid (testosterone [T], dihydrotestosterone [DHT], and estradiol [E2]) patterns were studied before the start and at days 1, 7, and 14 and months 2, 4, 6, and 12 on maintenance regimens. During the maintenance therapy, age-adjusted T levels were markedly suppressed to near-castrate levels in both treatment groups. Despite this marked suppression, age-adjusted T levels were consistently lower in men treated with the subcutaneous regimen from the 2nd week to the 12th month of treatment in morning pooled specimens as well as in detailed sampling over a 24-hour period after 12 months of continuous treatment. A similar pattern of enhanced suppression by the subcutaneous regimen was also observed for age-adjusted DHT, but not E2, levels during the study. Neither the magnitude nor the time course of T suppression by GnRH analog treatment could be entirely explained by the nature of the decline in plasma LH levels, which fell much less and more gradually over a 12-month period.(ABSTRACT TRUNCATED AT 250 WORDS)
AuthorsJ Rajfer, D J Handelsman, A Crum, B Steiner, M Peterson, R S Swerdloff
JournalFertility and sterility (Fertil Steril) Vol. 46 Issue 1 Pg. 104-10 (Jul 1986) ISSN: 0015-0282 [Print] United States
PMID3087785 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Gonadal Steroid Hormones
  • Dihydrotestosterone
  • Testosterone
  • Estradiol
  • Luteinizing Hormone
  • Buserelin
Topics
  • Administration, Intranasal
  • Aged
  • Buserelin (administration & dosage)
  • Dihydrotestosterone (blood)
  • Drug Evaluation
  • Estradiol (blood)
  • Gonadal Steroid Hormones (biosynthesis)
  • Humans
  • Injections, Subcutaneous
  • Luteinizing Hormone (blood)
  • Male
  • Middle Aged
  • Neoplasms, Hormone-Dependent (drug therapy, metabolism)
  • Prospective Studies
  • Prostatic Neoplasms (drug therapy, metabolism)
  • Random Allocation
  • Testis (metabolism)
  • Testosterone (blood)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: