[Anosmia or hyposmia after long-term oral administration of tegafur--improved anosmia].

Abstract

Seventeen patients who manifested anosmia or hyposmia after long-oral administration of Tegafur (FT-207) in postoperative chemotherapy for cancer were followed up. Anosmia improved in 9 of 17 patients (52.9%), and the recovery period was between 3 and 42 months after the manifestation, and between 1 and 35 months after discontinuation of FT-207. Rhinoscopy and radiography revealed no abnormal findings in the nasal septum, rima oflactoria, concha nasalis media, sinus ethmoidales, etc. As it took a long time to recover from these signs and symptoms, they were presumed to be due to reversible neurological anosmia or hyposmia.

• Authors: H Majima, H Aoki, H Sugenoya, O Shirai, B Toyoda
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 13 Issue 6 Pg. 2128-33 (Jun 1986) ISSN: 0385-0684 [Print] Japan
• PMID: 3087292 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Tegafur

Topics

• Aged
• Breast Neoplasms (drug therapy, physiopathology)
• Drug Administration Schedule
• Female
• Humans
• Male
• Middle Aged
• Olfaction Disorders (chemically induced, physiopathology)
• Rectal Neoplasms (drug therapy, physiopathology)
• Stomach Neoplasms (drug therapy, physiopathology)
• Tegafur (administration & dosage, adverse effects)