Drug delivery systems and novel formulations to improve treatment of rare corneal disease.

Abstract

As the field of ocular drug delivery grows so does the potential for novel drug discovery or reformulation in lesser-known diseases of the eye. In particular, rare corneal diseases are an interesting area of research because drug delivery is limited to the outermost tissue of the eye. This review will highlight the opportunities and challenges of drug reformulation and alternative treatment approaches for rare corneal diseases. The barriers to effective drug delivery and proposed solutions in development will be discussed along with an overview of corneal rare disease resources, their current treatments and ophthalmic drug delivery systems that could benefit such cases. The regulatory considerations for effective translation of orphan-designated products will also be discussed.

• Authors: Jorge Jimenez, Meera Sakthivel, Kanwal K Nischal, Morgan V Fedorchak
• Journal: Drug discovery today (Drug Discov Today) Vol. 24 Issue 8 Pg. 1564-1574 (Aug 2019) ISSN: 1878-5832 [Electronic] England
• PMID: 30872110 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2019 Elsevier Ltd. All rights reserved.

Chemical References

• Ophthalmic Solutions

Topics

• Animals
• Chemistry, Pharmaceutical (methods)
• Corneal Diseases (drug therapy)
• Drug Delivery Systems (methods)
• Eye (drug effects)
• Humans
• Ophthalmic Solutions (administration & dosage)
• Rare Diseases (drug therapy)