Neonatal and Maternal Morbidity Among Low-Risk Nulliparous Women at 39-41 Weeks of Gestation.

Abstract

OBJECTIVE:

To use a large national database to compare composite maternal or neonatal morbidity among low-risk, full-term women.

METHODS:

This cohort study, using the U.S. vital statistics datasets (2011-2015), evaluated low-risk nulliparous women with nonanomalous singleton gestations who labored at 39, 40, or 41 weeks of gestation (as reported in completed weeks of gestation; eg, 39 weeks include 39 0/7 to 39 6/7 weeks). The primary outcome, composite neonatal morbidity, included any of the following: Apgar score below 5 at 5 minutes, assisted ventilation longer than 6 hours, seizure, or mortality. The secondary outcome, composite maternal morbidity, included any of the following: intensive care unit admission, blood transfusion, uterine rupture, or unplanned hysterectomy. Multivariable Poisson regression was used to estimate the association between gestational age and morbidity (using adjusted relative risk [aRR] and 95% CI).

RESULTS:

Of 19.8 million live births during the study interval, 3.3 million met inclusion criteria: 43.5% were delivered at 39 weeks of gestation, 41.4% at 40 weeks, and 15.1% at 41 weeks. The overall rates of composite neonatal and maternal morbidity were 8.8 and 2.8 per 1,000 live births, respectively. Composite neonatal morbidity was higher for those delivered at 40 (aRR 1.22; 95% CI 1.19-1.25) and 41 (aRR 1.53; 95% CI 1.49-1.58) weeks of gestation when compared with 39 weeks. Composite maternal morbidity was also significantly higher with delivery at 40 (aRR 1.19; 95% CI 1.14-1.25) and 41 weeks of gestation (aRR 1.56; 95% CI 1.47-1.65).

CONCLUSION:

Among low-risk nulliparous women, the rate of composite neonatal and maternal morbidity increases, albeit modestly, from 39 through 41 weeks of gestation.

• Authors: Han-Yang Chen, William A Grobman, Sean C Blackwell, Suneet P Chauhan
• Journal: Obstetrics and gynecology (Obstet Gynecol) Vol. 133 Issue 4 Pg. 729-737 (04 2019) ISSN: 1873-233X [Electronic] United States
• PMID: 30870294 (Publication Type: Comparative Study, Journal Article)

Topics

• Adult
• Apgar Score
• Cohort Studies
• Databases, Factual
• Delivery, Obstetric (methods)
• Female
• Gestational Age
• Humans
• Infant
• Infant Health
• Infant, Newborn
• Live Birth
• Maternal Health
• Morbidity (trends)
• Parity
• Pregnancy
• Retrospective Studies
• Risk Assessment
• United States