In vitro inhibitory and bactericidal activity of cefpiramide and seven antipseudomonal agents against Pseudomonas aeruginosa.

Abstract	Cefpiramide was tested against 493 clinical isolates of Pseudomonas aeruginosa and the results of minimal inhibitory concentration, minimal bactericidal concentration, bactericidal rate, and time-kill synergy studies were compared with those obtained with seven other antipseudomonal agents. The minimal inhibitory concentrations of cefpiramide for P. aeruginosa were comparable to all of the agents tested. Minimal bactericidal concentration results were generally within one twofold dilution of the minimal inhibitory concentration values for all agents tested. Bactericidal rate studies showed that at concentrations of four times the minimal inhibitory concentration, all of the agents produced rapid killing. Results of time-kill synergy studies showed a marked synergistic interaction between cefpiramide and each of three aminoglycosides, gentamicin, tobramycin, and amikacin. These results suggest that cefpiramide may be useful in the therapy of infections due to P. aeruginosa.
Authors	M Pfaller, M Bale, T Preston, W Howard, F Koontz
Journal	Diagnostic microbiology and infectious disease (Diagn Microbiol Infect Dis) Vol. 5 Issue 1 Pg. 17-23 (May 1986) ISSN: 0732-8893 [Print] United States
PMID	3086026 (Publication Type: Comparative Study, Journal Article)
Chemical References	Aminoglycosides Anti-Bacterial Agents Cephalosporins Drug Combinations Gentamicins Thienamycins Imipenem Cefoperazone Amikacin Ceftazidime Azlocillin Cefsulodin cefpiramide Tobramycin Piperacillin
Topics	Amikacin (pharmacology) Aminoglycosides (pharmacology) Anti-Bacterial Agents (pharmacology) Azlocillin (pharmacology) Cefoperazone (pharmacology) Cefsulodin (pharmacology) Ceftazidime (pharmacology) Cephalosporins (pharmacology) Drug Combinations Drug Synergism Gentamicins (pharmacology) Humans Imipenem Microbial Sensitivity Tests Piperacillin (pharmacology) Pseudomonas aeruginosa (drug effects) Thienamycins (pharmacology) Time Factors Tobramycin (pharmacology)

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