HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Leu-M1 antigen in human neoplasms. An immunohistologic study of 400 cases.

Abstract
Several studies have shown that the Leu-M1 antigen, a monocyte/granulocyte-related marker, is consistently expressed by the neoplastic cells of patients with Hodgkin's disease (HD). It has been suggested that reactivity of Reed-Sternberg cells with Leu-M1 can be used in support of a morphologic interpretation of HD, and that it is helpful in the differential diagnosis of HD from morphologically similar lesions. To evaluate the significance of the Leu-M1 positivity of Reed-Sternberg cells in the diagnosis of HD, we investigated the distribution of Leu-M1 antigen in a series of patients with HD, non-Hodgkin's lymphomas, and nonhematopoietic neoplasms. We were able to demonstrate the presence of Leu-M1 antigen not only in the majority of patients with HD, but also in 12 of 18 (67%) peripheral T-cell lymphomas, as well as in a variety of nonhematopoietic neoplasms, which included 113 of 199 carcinomas, most of them (58%) adenocarcinomas. Only one of 34 sarcomas showed a focal positive reaction. Leu-M1-related antigen was not detected in any of 18 mesotheliomas, 15 germ cell tumors, 13 melanomas, three schwannomas, or three astrocytomas. Our study indicates that Leu-M1 positivity has no value in supporting the diagnosis of HD in situations where the histologic diagnosis of HD is doubtful. However, since anti-Leu-M1 reacted positively in the majority of adenocarcinomas but was absent in mesotheliomas, melanomas, and most sarcomas, this antigen could serve as a new marker that may be helpful in situations in which carcinoma is a part of the differential diagnosis.
AuthorsK Sheibani, H Battifora, J S Burke, H Rappaport
JournalThe American journal of surgical pathology (Am J Surg Pathol) Vol. 10 Issue 4 Pg. 227-36 (Apr 1986) ISSN: 0147-5185 [Print] United States
PMID3085523 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antigens, Differentiation, T-Lymphocyte
  • Antigens, Surface
Topics
  • Adenocarcinoma (analysis)
  • Antigens, Differentiation, T-Lymphocyte
  • Antigens, Surface (analysis)
  • Breast Neoplasms (analysis)
  • Histocytochemistry
  • Hodgkin Disease (analysis)
  • Humans
  • Immunologic Techniques
  • Lymph Nodes (pathology)
  • Mesothelioma (analysis)
  • Neoplasms (analysis, immunology)
  • Thymoma (analysis)
  • Thymus Neoplasms (analysis)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: