Abstract |
Brain-derived neurotrophic factor ( BDNF) is deemed to be associated with the psychopathology of bipolar I disorder (BD). However, studies focusing on accuracy of BDNF levels to differentiate these patients from healthy controls (HCs) are scarce. Over a discrete twelve-year period, we investigated serum BDNF levels in patients with BD and compared them to age-, sex- and body mass index (BMI)-matched HCs. There were lower serum BDNF levels in 83 samples with BD than in 222 HCs samples (5.7 ± 4.2 ng/ml vs. 12.2 ± 7.5 ng/ml, F = 46.784). Pearson's correlation test showed significant positive correlations between Young Mania Rating Scale scores and the BDNF levels among 61 manic patients (γ = 0.339). The receiver operating characteristic curve analysis showed BDNF levels demonstrated a moderate accuracy of being able to differentiate BD patients from HCs (AUC = 0.801). The most adequate cut-off points of the BDNF level were 6.74 ng/ml (sensitivity = 82.0%, specificity = 63.9%). Our results support that BDNF demonstrated moderate accuracy to distinguish BD patients from HCs. In the future, greater samples would be required to prove these results.
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Authors | Yu-Jie Chiou, Tiao-Lai Huang |
Journal | Psychiatry research
(Psychiatry Res)
Vol. 274
Pg. 395-399
(04 2019)
ISSN: 1872-7123 [Electronic] Ireland |
PMID | 30852433
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2019. Published by Elsevier B.V. |
Chemical References |
- Brain-Derived Neurotrophic Factor
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Topics |
- Adult
- Area Under Curve
- Bipolar Disorder
(blood)
- Body Mass Index
- Brain-Derived Neurotrophic Factor
(blood)
- Case-Control Studies
- Female
- Humans
- Male
- Middle Aged
- ROC Curve
- Statistics, Nonparametric
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