Des-O-methylolivoretin C is a new member of the teleocidin class of tumor promoters.

Abstract

Des-O-methylolivoretin C, a demethylated form of olivoretin C, is a naturally occurring compound in Streptomyces mediocidicus and Streptoverticillium olivoreticuli. Des-O-methylolivoretin C is a regioisomer of teleocidin B, which has the same activity as teleocidin. The tumor-promoting activity of des-O-methylolivoretin C was studied in a two-stage carcinogenesis experiment on mouse skin in comparison with that of teleocidin. Treatments with 7,12-dimethylbenz[a]anthracene (DMBA) plus des-O-methylolivoretin C and DMBA plus teleocidin induced tumors in 63.3% and 84.6% of the mice, respectively, in week 30. The difference in the tumor-promoting activities of des-O-methylolivoretin C and teleocidin is presumably related to the regioisomeric difference in the cyclohexene ring.

• Authors: M Ninomiya, H Fujiki, N S Paik, H Hakii, M Suganuma, Y Hitotsuyanagi, N Aimi, S Sakai, Y Endo, K Shudo
• Journal: Japanese journal of cancer research : Gann (Jpn J Cancer Res) Vol. 77 Issue 3 Pg. 222-5 (Mar 1986) ISSN: 0910-5050 [Print] Japan
• PMID: 3084411 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carcinogens
• Lyngbya Toxins
• teleocidins
• 9,10-Dimethyl-1,2-benzanthracene
• des-O-methylolivoretin C

Topics

• 9,10-Dimethyl-1,2-benzanthracene
• Animals
• Carcinogens
• Female
• Lyngbya Toxins (toxicity)
• Mice
• Mice, Inbred Strains
• Molecular Conformation
• Skin Neoplasms (chemically induced)
• Structure-Activity Relationship