HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Enzymic imbalance in serine metabolism in rat hepatomas.

Abstract
The activity of 3-phosphoglycerate dehydrogenase was high in tissues of high cell-renewal capacity, and was increased in neonatal and regenerating liver and, more markedly, in hepatomas. Serine hydroxymethyltransferase activity was present in hepatomas, whereas other enzymes of serine utilization (serine dehydratase and serine aminotransferase) were absent. This enzymic imbalance couples serine biosynthesis preferentially to nucleotide precursor formation in cancer cells.
AuthorsK Snell, G Weber
JournalThe Biochemical journal (Biochem J) Vol. 233 Issue 2 Pg. 617-20 (Jan 15 1986) ISSN: 0264-6021 [Print] England
PMID3082329 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Serine
  • Carbohydrate Dehydrogenases
  • Phosphoglycerate Dehydrogenase
  • Glycine Hydroxymethyltransferase
  • Transaminases
  • serine-pyruvate aminotransferase
  • L-Serine Dehydratase
Topics
  • Animals
  • Carbohydrate Dehydrogenases (metabolism)
  • Cell Line
  • Glycine Hydroxymethyltransferase (metabolism)
  • L-Serine Dehydratase (metabolism)
  • Liver Neoplasms, Experimental (enzymology)
  • Liver Regeneration
  • Male
  • Phosphoglycerate Dehydrogenase
  • Rats
  • Rats, Inbred Strains
  • Serine (metabolism)
  • Transaminases (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: